This section of my website provides an introduction to my immunological research, covering my work at Imperial College London and The University of Medicine and Dentistry of New Jersey.
The site has information about some of the research projects I have worked on, my published papers, conference abstracts and book chapters as well as this page, which gives a brief overview of my academic CV.
PhD Imperial College London,, June 2000
Department of Immunology
PhD in Medicine
MSc Royal Postgraduate Medical School London, Feb 1996
MSc in Immunology
Grade of Distinction Awarded
BSc University of Southampton, 1993
BSc in Biology
Postdoctoral Research Fellow, working for Professor Grant Gallagher. My research here was aimed at understanding the function of novel, newly identified cytokines including the IL-10 family members IL-19 and IL-20 and the Interferon Lambda family comprising IL-28A, IL-28B and IL-29. In addition to functional studies on these cytokines, my work was also aimed at understanding the genetics of small molecules involved in the immune response, including antimicrobial peptides such as beta-defensins and lactoferrin
Temporary Research Consultant position, working with Dr David Webster, Department of Clinical Immunology. Established and taught cellular techniques within the laboratory for the study of dendritic cell and T cell responses in Common Variable Immunodeficiency (CVID) patients
Postdoctoral Research Fellow, working for Professor Mary Ritter, Department of Immunology. The research grant for this study was awarded to continue the research undertaken during my Action Research Training Fellowship.
My work was aimed at taking my initial studies on cytokine responses during the alloresponse through to clinical work developing new tests aimed at improving donor selection for bone marrow transplantation (stem cell transplantation) for leukaemia patients.
I also undertook several basic scientific studies during this time, including work examining the function of the dendritic cell receptor, CD205 and a number of studies examining basic dendritic cell function during transplantation
Awards and Competitive Scholarships
Bridging both basic science and clinical immunology, the research during my Action Research Fellowship was aimed at improving selection of donors prior to stem cell transplantation, .
My clinical work was based on analysis of the role of cytokines during Stem Cell Transplantation. This work resulted in the development of novel tests to aid donor selection prior to transplantation for Leukaemia
The Research Training Fellowship was awarded by HRM Prince Philip, at Buckingham Palace, London and provided the funding for my PhD studies
Annual prize scholarship for advanced study within The Royal Postgraduate Medical School
Teaching and Lecturing
- Lecturer for BSc, MSc and Medical students at Imperial College, London
- Direct supervisor for MSc students during their 7 month research projects
- Invited PhD transfer viva examiner at Institute of Animal Health
- Supervision of PhD students
- Teaching of BSc and MSc and Medical degree students.
- Examiner for Medical students in their taught course modules
- Media Training as part of my Action Research PhD Fellowship - invited to talk on news and current affairs radio programmes to publicise the work that Action Research funds in the field of transplantation research
- Professional Presentation Skills training - invited speaker at charitable society events in order to educate on the progress being made in stem cell transplantation research
1. Jordan WJ, Eskdale J, Sriniva S,. Boniotto, M. Rodia, D. Kellner, G. Gallagher. Interferon lambda-1 (IFN-lambda1/IL-29) modulaties the Th1/Th2 response. Genes and Immunity. 2007 March 15; [Epub ahead of print]
2. Butler M, Morel AS, Jordan WJ, Eren E, Hue S, Shrimpton RE, Ritter MA. Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation. Immunology. 2007 Mar;120(3): 362-71.
3. W. J. Jordan, J. Eskdale, M. Boniotto, M. Rodia, D. Kellner, and G. Gallagher. Modulation of the human cytokine response by Interferon Lambda-1 (IL-29). Genes and Immunity. 2007 Jan;8(1):13-20.
4. G. Gallagher, J. Eskdale, W. Jordan, M. Boniotto, M. Rodia, D. Kellner, E. Witte, R. Sabat, K. Wolk. Human Interleukin-19: Structure, Function and Disease Associations. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006 5: 233-242,
5. Miki Boniotto M* and Bill Jordan *. Human beta-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells. Antimicrob Agents Chemother. 2006 Apr;50 (4):1433-41. *Denotes both authors contributed equally to this paper
6. A. Tamir, W. J. Jordan, M. Ritter, N. Habib, R. I. Lechler, G. R. Foster, G. Lombardi. Interferon-2a is sufficient for promoting dendritic cell immunogenicity. Clin Exp Immunol. 2005 Dec;142(3):471-80.
7. Tan PH, Yates JB, Xue SA, Chan C, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJ. Creation of tolerogenic human DC via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood. 2005 Nov 1;106(9):2936-43
8. William J. Jordan, Joyce Eskdale, Rebecka Pestoff, Lei Wu, Daniel H. Fine and Grant Gallagher. A non-conservative coding single nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African American, but not a Caucasian population. Genes and Immunity. 2005 Oct 6; PMID: 16208406
9. Yannis Kokkinopoulos, Bill Jordan and Mary Ritter. Toll-Like Receptor Expression Patterns in Human Dendritic Cells and monocytes. Molecular Immunology 2005 May;42(8):957-68
10. Jordan WJ, Eskdale J, Boniotto M, Lennon GP, Peat J, Campbell JD, Gallagher G. Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10. Eur J Immunol. 2005 Apr 13;35(5):1576-1582
11. Boniotto M, Hazbon MH, Jordan WJ, Lennon GP, Eskdale J, Alland D, Gallagher G. Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease. Clin Diagn Lab Immunol. 2004 Jul;11(4):766-9.
12. Gallagher G, Eskdale J, Jordan W, Peat J, Campbell J, Boniotto M, Lennon GP, Dickensheets H, Donnelly RP. Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses. Int Immunopharmacol. 2004 May;4(5):615-26.
13. William J Jordan, Paul A. Brookes, Richard M. Szydlo, John M. Goldman, Robert I. Lechler and Mary A. Ritter. IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. Blood. 2004 Jan 15;103(2):717-2
14. Rogers, N.J., Jackson, I.M., Jordan, W.J., Hawadle, M.A. Dorling, A. and Lechler, R.I. Cross-species co-stimulation: relative contributions of CD80, CD86 and CD40. Transplantation. 2003. June;27;75(12):2068-76
15. Rogers, N.J., Jackson, I.M., Jordan, W.J., Lombardi, G., Delikouras, A and Lechler, R.I. CD40 can co-stimulate human memory T cells and favors IL-10 secretion. European Journal of Immunology. 2003 Apr;33(4):1094-104.
16. Jordan WJ. and Ritter MA. Optimal analysis of composite cytokine responses during alloreactivity. J Immunol Methods. 2002 Feb 1;260(1-2):1-14.
17. Dorling A, Jordan W, Brookes P, Delikouras A, Lechler RI. "Accomodated" pig endothelial cells promote nitric oxide-dependent Th-2 cytokine responses from human T cells. Transplantation. 2001 Nov 27;72(10):1597-602